Vitamin B6 (Pyridoxine)

Vitamin B6 (Pyridoxine) Claims

  • maintain / support energy levels
  • maintain / support energy production
  • maintain / support nervous system function
  • decreases / reduces / relieves morning sickness
  • Maintains and supports energy levels and energy production

  • During pregnancy, vitamin B6 helps maintain adequate energy levels by supporting key metabolic processes that produce cellular energy. Vitamin B6, in its active form as pyridoxal phosphate (PLP), is involved in glucose metabolism and the citric acid cycle, two major pathways that generate adenosine triphosphate (ATP), which is energy.

    Vitamin B6 also helps produce amino acids that are precursors for neurotransmitters like serotonin, dopamine and norepinephrine. These neurotransmitters influence mood, appetite and energy levels. Serotonin and dopamine in particular promote feelings of wellbeing, motivation and alertness.

    Adequate vitamin B6 intake during pregnancy is important as the fetus and placenta have high energy demands for growth and function. 

    Vitamin B6 Maintains and supports nervous system function

    Vitamin B6 plays an important role in maintaining and supporting nervous system function for both the mother and developing baby during pregnancy. 

    There are two major ways it does this:

    First, vitamin B6 is needed to synthesize neurotransmitters like serotonin, dopamine, norepinephrine and GABA that transmit signals between neurons. Adequate levels of these neurotransmitters are essential for proper brain and nervous system development in the fetus. They also influence mood, sleep and stress responses in the mother which impact foetal health.

    Second, vitamin B6 aids in the formation of myelin sheaths that coat nerve fibers. Myelin allows for faster and more efficient nerve conduction. During pregnancy, the fetus undergoes rapid brain growth and myelination. Vitamin B6 helps provide the building blocks needed for this process. In the mother, myelin sheath maintenance helps preserve nervous system function under the physiological stresses of pregnancy.

    In summary, vitamin B6 supports both neurotransmitter synthesis and myelination - two key processes that enable proper nervous system and brain development in the baby. For the mother, adequate vitamin B6 helps maintain mood, sleep patterns and nerve function vital to a healthy pregnancy. 

    Good food sources of vitamin B6 include chicken, tuna, bananas, spinach and fortified cereals. Vitamin B6 supplements may be needed to achieve the recommended intake, especially for women with nausea and food aversions during pregnancy.

    Vitamin B6 Relieves morning sickness

    Vitamin B6 helps alleviate symptoms of morning sickness in several ways. First, it aids in the production of neurotransmitters like serotonin, dopamine, and GABA. Low levels of these neurotransmitters have been linked to nausea and vomiting during pregnancy. By boosting neurotransmitter synthesis, vitamin B6 can improve signaling between neurons in the areas of the brain that regulate nausea.

    Second, vitamin B6 supports the metabolism of amino acids and proteins. During pregnancy, hormonal changes can disrupt amino acid balance in the body, which may contribute to morning sickness. Vitamin B6 helps maintain proper amino acid and protein metabolism, which can stabilize metabolic processes and alleviate nausea.

    Third, vitamin B6 plays a role in breaking down a chemical called histamine. Histamine levels often rise during pregnancy and have been associated with morning sickness. By aiding the breakdown of histamine, vitamin B6 supplementation may reduce histamine-induced feelings of nausea.

    While research on the effectiveness of vitamin B6 for morning sickness is mixed, there are plausible mechanisms by which it could provide relief. For pregnant women experiencing nausea and vomiting, supplementing with vitamin B6 may help alleviate symptoms, particularly when used as part of a comprehensive treatment plan.

    References:

    Braun, L., & Cohen, M. (2014). Herbs & Natural Supplements – An Evidence-Based Guide. Elsevier.

    Food Standards Australia New Zealand. (2017). Schedule 4 Nutrition health and related claims. Schedule 1 RDI and ESADDI. Australia Government. Federal Register of Legislation.

    Gropper, S., Smith, J., & Groff, J. (2009). Advanced Nutrition and Human Metabolism (5th ed.). Wadsworth Cengage Learning.

    Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. (1998). Introduction to Dietary Reference Intakes. In Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academies Press (US).

    Jamison, J. (2003). Clinical Guide to Nutrition & Dietary Supplements in Disease Management.
    Murray, M. (1996). Encyclopedia of Nutritional Supplements. Harmony.

    Reavley, N. (1998). The New Encyclopedia of Vitamins, Minerals, Supplements and Herbs. Bookman Press.

    Scientific Committee. (2013). Standard 1.2.7 – Nutrition, Health and Related Claims (FSANZ).

    Scientific Committee. (2011). Global Information Hub on Integrated Medicine.
    Thorne Research. (2001). Vitamin B6 (Pyridoxine; Pyridoxal 5' Phosphate). Alternative Medicine Review, 6(1).