Inositol

Inositol, a member of the B-vitamin complex, is vital for preconception, pregnancy, and postpartum due to its involvement in cellular signaling, insulin sensitivity, and neural development. 

Inositol plays a key role in insulin-mediated pathways, supporting glucose metabolism, and overall metabolic health during preconception, which can assist with managing conditions like polycystic ovary syndrome (PCOS), which is often associated with fertility issues.

Inositol and Pregnancy

During pregnancy, inositol contributes to neural tube development and may help prevent neural tube defects in the developing fetus. Its role in neurotransmitter signaling also supports cognitive and behavioral aspects of fetal brain development.

Inositol, particularly myo-inositol, has shown promise in supporting women with gestational diabetes mellitus (GDM) or in the prevention of GDM. It does this by supporting glucose and insulin metabolism, and improving insulin sensitivity. Gestational diabetes is a condition that develops during pregnancy when the body is unable to produce enough insulin to meet the increased demands, leading to elevated blood glucose levels. 

Inositol and Postmartum

Postpartum, inositol remains relevant for maternal mental health, potentially assisting in mood regulation. Adequate inositol levels may be particularly important for women with a history of postpartum depression.

References:

Costantino, D., Guaraldi, C., & Costantino, M. (2019). Mental health of mothers: Inositol and beyond. International Journal of Gynecology & Obstetrics, 144(3), 277–282.

Laganà, A. S., Vitale, S. G., & Ban Frangež, H. (2019). D-chiro-inositol and its significance in polycystic ovary syndrome: a systematic review. Gynecological Endocrinology, 35(8), 565–571. https://pubmed.ncbi.nlm.nih.gov/21142777/

Levine, J., Aviram, A., & Holcberg, G. (2011). Inositols: From Physiology to Rational Therapy in Obstetrics. Gynecological Endocrinology, 27(11), 775–780.